3,5-Dimethylphenylboronic acid, identified by CAS 172975-69-8, is an aromatic boronic acid used primarily as a building block in organic synthesis. Its two methyl substituents and boronic acid group give researchers a defined substrate for palladium-catalyzed cross-coupling and related synthetic routes. At Maison Chemical, I help buyers evaluate this material by identity, application fit, analytical requirements, packaging, documentation, and supply continuity rather than by CAS number alone.
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The molecular formula generally associated with this compound is C8H11BO2, with a calculated molecular weight of approximately 149.98 g/mol. Buyers should still confirm the formula, molecular weight, purity basis, and analytical method against the supplier’s current specification and certificate of analysis. The right purchasing decision depends on the intended reaction, required scale, impurity tolerance, and whether the material is needed for research, process development, or commercial manufacturing.
This guide is intended for procurement teams, medicinal and process chemists, laboratory managers, quality professionals, and distributors sourcing 3,5-dimethylphenylboronic acid. It is also useful for companies comparing catalog-grade material with custom or repeat-supply options. I focus on practical questions: what the compound does, which specifications matter, how to screen suppliers, and how to reduce avoidable sourcing risk.
3,5-Dimethylphenylboronic acid belongs to the family of aryl boronic acids. The boronic acid functionality can participate in carbon–carbon bond-forming reactions, particularly Suzuki–Miyaura coupling, where an aryl boronic acid is combined with a suitable halide or related electrophile in the presence of a catalytic system. The resulting substituted biaryl or aryl-containing product can be useful as an intermediate in pharmaceutical, agrochemical, materials, and specialty organic synthesis.
The 3,5-dimethyl substitution pattern is important because it changes the steric and electronic environment of the aromatic ring. This can affect reaction behavior, downstream molecular properties, and the design of a target intermediate. I therefore recommend treating this compound as a structure-specific reagent, not as an interchangeable substitute for other methylphenylboronic acids.
These applications describe chemical use categories rather than guaranteed performance in a particular reaction. Reaction yield, selectivity, and stability depend on the partner substrate, catalyst, base, solvent, water content, temperature, work-up, and purification method. A small application trial is advisable before a large purchase.
A buyer should separate confirmed identity data from commercial release criteria. Identity normally includes the chemical name, CAS number 172975-69-8, molecular formula, molecular weight, and structure. Release specifications may include assay or purity, appearance, water content, residual solvents, elemental impurities, and chromatographic impurity limits, depending on the intended use.
| Specification Area | What to Confirm | Why It Matters |
|---|---|---|
| Identity | CAS, structure, formula, molecular weight, and identity test | Prevents substitution or positional-isomer confusion |
| Purity | Assay basis and chromatographic impurity profile | Supports reaction reproducibility and downstream control |
| Moisture | Water specification and test method | Relevant to moisture-sensitive reagents and repeatability |
| Physical form | Appearance, color, and packaging condition | Helps receiving inspection and laboratory handling |
| Documentation | CoA, SDS, batch information, and applicable statements | Supports quality review, import, and internal traceability |
Purity should not be evaluated without reviewing the test method. For example, a reported value of 98% may be based on area normalization, while another supplier may use a different calculation basis or include a separate assay correction. I recommend asking for a representative certificate of analysis and confirming whether the listed result is a specification limit or a single batch result.
First, identify the exact bond-forming step and the reaction partner that will be used with the boronic acid. Record the planned scale, catalyst system, base, solvent, temperature, and purification route. This information helps determine whether a standard research quantity is sufficient or whether a controlled, repeatable supply is more appropriate.
For early discovery work, buyers may prioritize availability, pack size, and a basic analytical package. For process development or regulated environments, the purchasing specification may need tighter impurity controls, defined analytical methods, batch traceability, change notification, and controlled packaging. I suggest agreeing on these requirements before requesting a quotation so suppliers can price and schedule the correct grade.
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Ask how the material is packed, sealed, labeled, and protected during transport. The buyer should follow the supplier’s current SDS and label instructions for storage, handling, personal protective equipment, and waste management. If the project involves repeated opening of a container, discuss pack sizes that reduce unnecessary exposure to air, moisture, or contamination.
Before committing to a larger volume, compare the supplier’s sample against the project’s acceptance criteria. Review identity, purity, water content where relevant, appearance, and reaction performance using the buyer’s own procedure. A qualification sample cannot guarantee future process results, but it can reveal differences in analytical basis, handling, or batch consistency before commercial dependence develops.
Supplier selection should cover more than the lowest quoted price. I recommend evaluating manufacturing or sourcing transparency, batch availability, quality-system practices, analytical capability, packaging control, export experience, and response time. For a research purchase, a supplier that can provide a clear CoA and dependable small packs may be the best fit; for a development program, continuity and change control may carry greater weight.
The price of 3,5-dimethylphenylboronic acid can vary with quantity, purity target, packaging, analytical requirements, production status, and shipping destination. A catalog quote and a project-specific quote may therefore differ even when the CAS number is the same. I advise buyers to request a tiered quotation, such as laboratory quantity, development quantity, and larger repeat quantity, without assuming that the smallest price-per-gram is the lowest total cost.
MOQ and lead time should be confirmed in writing for the exact specification. Stock availability may support a shorter dispatch schedule, while a custom batch may require additional production, testing, and release time. A practical purchasing plan should include time for sample approval, import clearance, incoming inspection, and any customer-specific documentation.
At Maison Chemical, I approach this product as part of a broader organic boronic acid supply program. We can help clarify the requested identity, quantity, purity expectation, packaging, documentation, and destination before preparing a commercial quotation. Where the application requires additional review, I encourage buyers to share the reaction context and acceptance criteria so the inquiry can be assessed on a technical and commercial basis.
Our support can include product information review, specification alignment, representative documentation, packaging discussion, and supply planning for repeat requirements. These services do not replace the buyer’s own qualification, regulatory review, or laboratory validation. They are intended to make communication more precise and reduce avoidable misunderstandings during sourcing.
3,5-Dimethylphenylboronic acid CAS 172975-69-8 is a structure-specific aryl boronic acid used mainly as a synthetic building block, especially in cross-coupling and related organic chemistry. The most important buying checks are identity confirmation, analytical basis, impurity and moisture requirements, documentation, packaging, MOQ, and lead time. Buyers should also distinguish a research-grade purchase from a development or repeat-supply requirement.
My recommended next step is to send the supplier your target quantity, required purity, intended application stage, packaging preference, destination, and documentation needs. At Maison Chemical, we can then review the request and provide a quotation aligned with the actual specification rather than a generic CAS-number match. This approach gives your team a clearer basis for sample evaluation, supplier comparison, and future purchasing decisions.
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