4-Tolylboronic acid, also known as 4-methylphenylboronic acid or p-tolylboronic acid, is an aryl boronic acid used mainly as a coupling partner in synthetic chemistry. Its CAS number is 5720-05-8, and its molecular formula is C7H9BO2 with a relative molecular mass of approximately 135.96 g/mol. I supply this material for research, process development, and manufacturing programs where identity, purity, documentation, packaging, and delivery consistency must be evaluated together.
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The primary value of 4-tolylboronic acid is its boronic acid functional group, which can participate in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions with suitable aryl or vinyl halides. The resulting carbon–carbon bond-forming step can introduce a para-methylphenyl group into pharmaceutical intermediates, agrochemical intermediates, specialty molecules, and research compounds. Actual performance depends on the reaction system, substrate, catalyst, base, solvent, water content, and handling conditions.
This guide is intended for procurement teams, process chemists, R&D laboratories, contract manufacturers, and distributors sourcing 4-Tolylboronic acid CAS 5720-05-8. It is especially useful when a buyer needs to compare material specifications rather than select only by product name. I recommend reviewing this information alongside the intended reaction, required quantity, internal quality standards, and applicable regional requirements.
4-Tolylboronic acid contains a boronic acid group attached to the para position of a tolyl ring. In practical terms, the methyl substituent affects the electronic and steric character of the aromatic group, while the boronic acid group provides the reactive handle used in cross-coupling chemistry. The compound is commonly handled as a solid, but appearance alone does not confirm identity or suitability for a specific reaction.
For purchasing and formulation records, the key identifiers are CAS 5720-05-8, the systematic name commonly associated with the para isomer, the molecular formula C7H9BO2, and the approximate molecular weight of 135.96 g/mol. These identifiers should be checked against the supplier’s certificate of analysis and product specification. This is important because positional isomers and related aryl boronic acids can have similar names but different reactivity and analytical profiles.
A buyer should distinguish between general reference information and lot-specific release data. Physical properties such as melting behavior, color, particle form, residual solvents, water content, and assay may vary according to manufacturing route, purification, storage, and test method. I therefore recommend using a current specification sheet and certificate of analysis as the controlling documents for an actual order.
| Specification or identifier | Reference information | Why it matters |
|---|---|---|
| CAS number | 5720-05-8 | Confirms the intended chemical identity |
| Molecular formula | C7H9BO2 | Supports technical review and inventory control |
| Approximate molecular weight | 135.96 g/mol | Required for stoichiometric calculations |
| Physical form | Typically supplied as a solid | Relevant to weighing, packaging, and handling |
Some commercial references report a high-temperature melting range for 4-Tolylboronic acid, but the exact value should not be treated as a universal release specification without confirming the test method and product grade. A buyer may also request an assay target, for example a specification expressed as a percentage, but the acceptable limit must be agreed before production. Other useful tests can include identity by spectroscopy, chromatographic purity, water content, residual solvents, and elemental or inorganic impurity evaluation where relevant.
The best-known use of 4-Tolylboronic acid is as an aryl donor in Suzuki–Miyaura coupling. In a suitable reaction, the arylboronic acid couples with an aryl, heteroaryl, or vinyl halide to form a new carbon–carbon bond. The precise conversion and selectivity cannot be guaranteed from the reagent alone because catalyst loading, ligand selection, base, temperature, substrate structure, and work-up conditions all influence the result.
4-Tolylboronic acid can be used during the preparation of pharmaceutical building blocks and other advanced intermediates that contain a para-methyl-substituted biaryl or related aromatic structure. It may also be useful in medicinal chemistry libraries, where small structural changes are introduced to compare biological or physicochemical properties. For regulated or quality-sensitive programs, buyers should define the required grade, traceability, impurity profile, and documentation before ordering.
Academic, industrial, and contract research laboratories may purchase this compound for route screening, reaction optimization, and scale-up studies. A small research pack may prioritize availability and analytical data, while a process program may place greater emphasis on batch consistency, supply continuity, packaging, and change-control communication. Matching the specification to the development stage can help avoid paying for requirements that are not yet technically necessary.
Not every project needs the same commercial specification. When selecting 4-Tolylboronic acid, I suggest evaluating four categories: identity, purity, physical handling, and supply support. These categories provide a more reliable basis for comparison than price per kilogram alone.
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For route development, a standard research grade may be adequate if the material is supported by clear analytical data. For scale-up or repeated manufacturing, the buyer should consider a written specification, retained sample policy, batch-to-batch comparison, and notification process for significant changes. If the compound is used in a sensitive catalytic system, water and impurity controls may deserve particular attention.
4-Tolylboronic acid should be handled according to its current safety data sheet and the buyer’s site procedures. Personnel should use appropriate protective equipment, avoid generating dust, and work with suitable ventilation and containment practices. I do not recommend relying on a generic handling assumption because the final risk profile also depends on particle size, packaging, exposure route, and the surrounding process.
The material should be kept in a tightly closed, correctly labeled container under the storage conditions specified by the supplier. Moisture exposure may be relevant for boronic acid materials, so buyers should confirm whether a dry environment, desiccant, inert-gas protection, or controlled opening procedure is appropriate for their application. Any unusual change in color, texture, packaging integrity, or analytical result should be investigated before use.
Pricing for 4-Tolylboronic acid is normally influenced by order quantity, purity target, packaging, analytical testing, production scheduling, and shipping destination. A laboratory pack and a recurring manufacturing supply may have different unit economics and lead-time expectations. I recommend requesting a quotation that clearly separates material cost, packaging, testing, freight, and any special documentation.
MOQ should be discussed together with the intended project stage. A lower initial quantity can support feasibility work, while a larger forecast may help suppliers plan production and reserve capacity. Lead time should be confirmed in writing because stock status, batch release, export documentation, and destination requirements can affect the actual delivery schedule.
A capable supplier should be able to provide a consistent product identity and explain the available specification. I recommend asking whether each shipment is supported by a lot-specific certificate of analysis and whether the test methods are identified. Buyers may also ask about sample availability, retained samples, complaint handling, and the process used to communicate material or packaging changes.
Commercial evaluation should include more than the quoted unit price. Compare the supplier’s MOQ, standard pack sizes, production lead time, export experience, shipment terms, and ability to support repeat orders. Maison Chemical supports B2B buyers by coordinating product information, quotation details, packaging discussions, documentation review, and delivery planning for chemical sourcing programs.
The right supplier is one that can match the material to the buyer’s actual use case. For example, a screening project may need a small quantity and fast documentation, whereas a manufacturing program may require forecast planning, repeatable specifications, and controlled communication. Before placing an order, provide the intended quantity, target purity, delivery country, required documents, and any special packaging or analytical needs.
4-Tolylboronic acid CAS 5720-05-8 is a useful aryl boronic acid for carbon–carbon bond formation, particularly in Suzuki–Miyaura coupling and related synthetic programs. Its principal identifiers are formula C7H9BO2, approximate molecular weight 135.96 g/mol, and CAS number 5720-05-8. However, suitability depends on verified lot data, purity, moisture and impurity controls, packaging, and the reaction requirements of the buyer.
My recommended next step is to prepare a clear purchasing specification before comparing quotations. Include the required quantity, purity target, documentation, packaging, delivery location, and expected repeat demand. Maison Chemical can review these requirements and provide a practical supply proposal for 4-Tolylboronic acid, including available grade information, commercial terms, and support for your next procurement decision.
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