2,6-Bis(benzyloxy)pyridine-3-boronic acid, identified by CAS 2096339-92-1, is an advanced heteroaryl boronic acid used primarily as a synthetic building block. Its pyridine ring contains two benzyloxy substituents at the 2 and 6 positions and a boronic acid group at the 3 position. This combination gives medicinal chemistry and process development teams a protected, functionalized pyridine intermediate for further bond-forming reactions, especially reactions that use the reactivity of an aryl boronic acid. As Maison Chemical, we support qualified buyers with product identification, specification review, sample discussions, and quotation preparation based on their project requirements.
The defining feature of this compound is its 3-pyridyl boronic acid core. The boronic acid group can participate in palladium-catalyzed cross-coupling chemistry, while the two benzyloxy groups modify the electronic and steric environment of the pyridine ring. The benzyl groups may also function as protecting groups, depending on the intended synthetic route and the downstream deprotection strategy.
CAS 2096339-92-1 should be used as the primary identifier when requesting a quotation or comparing supplier documents. Buyers should also confirm the supplier’s internal product code, lot-specific analytical data, salt or solvate status, and packaging configuration. Because specialty intermediates can be listed under similar names, confirming the CAS number and structure before purchase helps reduce substitution and documentation risks.
The boronic acid group is the main synthetic handle in this molecule. In an appropriate cross-coupling process, it may be used to construct a carbon–carbon bond with a suitable aryl, heteroaryl, or vinyl coupling partner. The exact reaction performance depends on the coupling partner, catalyst system, base, solvent, temperature, concentration, and purification method.
The benzyloxy groups can provide a protected form of hydroxyl functionality attached to the pyridine framework. Protection can be useful when a synthetic sequence requires selective reaction at the boronic acid while limiting unwanted participation from free hydroxyl groups. Whether the benzyl groups are retained or removed depends on the target molecule and the overall route design.
Pyridine-containing fragments are common in medicinal chemistry and agrochemical research because the ring nitrogen can influence polarity, hydrogen-bonding behavior, and molecular recognition. This compound offers a pre-functionalized heteroaryl scaffold rather than an unsubstituted pyridine. That may help researchers evaluate analogues more efficiently during route exploration, provided that the compound’s stability and reactivity are confirmed in the intended conditions.
The most direct application is as an intermediate in pharmaceutical and specialty chemical synthesis. Research teams may use it to introduce a substituted pyridine fragment into a larger molecule through cross-coupling. It may also be relevant to discovery chemistry, where several related analogues are prepared to study structure–activity relationships.
Another potential use is route scouting for advanced intermediates. A buyer may compare this protected boronic acid with a free hydroxypyridine boronic acid or another protected derivative to determine which option provides better chemoselectivity, handling, or purification. These decisions should be based on experimental screening rather than on the compound name alone.
It is important to describe these as potential uses rather than guaranteed applications. The appropriate use depends on the customer’s target structure, reaction conditions, scale, analytical requirements, and regulatory environment. This material should not be treated as an active pharmaceutical ingredient, finished formulation ingredient, or approved therapeutic substance unless separate documentation supports that classification.
For this type of specialty organic boronic acid, the key distinction is usually not a broad product “grade” but the level of documentation and quality control required by the project. A discovery-stage buyer may initially need a small research quantity and basic analytical confirmation. A process-development buyer may require tighter impurity control, batch consistency, traceability, and a more detailed document package.
| Buyer requirement | What to confirm |
|---|---|
| Identity | CAS number, chemical name, structure, and lot-specific analytical data |
| Purity | Assay method, chromatographic purity, and reporting basis |
| Physical form | Appearance, solid or powder description, and any known solid-state variation |
| Residuals | Residual solvents, water content, inorganic residues, and catalyst-related impurities where relevant |
| Packaging | Container type, closure, protection from moisture or light, and shipment conditions |
Do not assume a specific assay, melting point, color, or storage condition without reviewing the current product specification and SDS. Boronic acids can show sensitivity to moisture, heat, or prolonged storage depending on their structure and packaging. For an initial feasibility study, a buyer may request a 100 mg–1 g evaluation quantity, while larger requirements should be discussed according to the synthesis schedule and available batch size.
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Laboratory personnel should handle 2,6-Bis(benzyloxy)pyridine-3-boronic acid according to the supplier’s SDS and internal chemical safety procedures. Appropriate controls may include suitable gloves, eye protection, controlled weighing, and measures that limit dust generation. The correct precautions depend on the completed hazard assessment, because the chemical name alone does not provide a complete safety profile.
Packaging should protect the material from contamination and environmental exposure. If the supplier’s documentation recommends refrigerated storage, a buyer may use a controlled range such as 2–8 °C, but this should not be treated as a universal requirement without product-specific confirmation. The original container should remain properly closed, and the material should be inspected for changes in appearance or analytical behavior before use.
For sensitive synthetic work, buyers should record the lot number, opening date, storage history, and any unusual handling observations. This information can help distinguish raw-material variability from changes caused by the reaction or purification process. A small incoming inspection using an appropriate analytical method may be valuable before committing the material to a larger campaign.
Start with the CAS number 2096339-92-1, the full chemical name, and the expected structure. Ask whether the quoted material is the free boronic acid rather than a protected boronate ester, salt, solvate, or another related derivative. A structure confirmation is especially important when the purchasing system contains similar pyridine building blocks.
Request a current certificate of analysis or equivalent lot documentation where available. The document should clearly identify the material and show the analytical basis for the reported purity. If the project is moving toward scale-up, ask whether the same specification and manufacturing route can be maintained across future batches.
Price is only one sourcing factor for an advanced intermediate. Buyers should also assess minimum order quantity, sample availability, lead-time assumptions, packaging, export documentation, and the supplier’s ability to answer technical questions. For regulated or audit-sensitive projects, document consistency and traceability may be more important than a small difference in unit price.
Maison Chemical supports B2B inquiries for specialty organic boronic acids and related chemical intermediates. We can review the requested CAS number, clarify the desired quantity and application stage, and help align the inquiry with available specifications and documentation. Our role is to provide practical information for evaluation and sourcing, while final suitability remains subject to the buyer’s own analytical and process requirements.
When contacting Maison Chemical, please include the required quantity, target purity, destination country, intended research or manufacturing stage, packaging preference, and documentation requirements. If you need a sample before a larger order, state the evaluation quantity and timeline clearly. This information allows us to prepare a more relevant response instead of offering a generic quotation.
2,6-Bis(benzyloxy)pyridine-3-boronic acid CAS 2096339-92-1 is best understood as a specialized synthetic building block, not as a finished-use chemical. Its value comes from combining a reactive boronic acid group with a protected, substituted pyridine framework. It may be a suitable choice when your route requires this specific substitution pattern and when the supplier can provide identity and quality information that matches your process needs.
The next step is to compare the required structure with your route, define the target quantity and specification, and request current product documentation. Maison Chemical can assist with a focused B2B inquiry covering availability, packaging, sample requirements, and commercial supply options. Please contact us with your CAS number, quantity, destination, and technical requirements so we can evaluate the most appropriate supply solution.
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