Pyridine-3-boronic acid CAS 1692-25-7 is an organoboron building block used primarily in synthetic chemistry, especially palladium-catalyzed Suzuki–Miyaura cross-coupling reactions. It contains a pyridine ring and a boronic acid functional group, allowing chemists to introduce a 3-pyridyl group into more complex molecules. Its commonly used molecular formula is C5H6BNO2, with a calculated molecular weight of approximately 122.92 g/mol.
At Maison Chemical, we view this material as a practical intermediate for research, process development, and pharmaceutical or agrochemical molecule synthesis. Buyers should evaluate not only identity and assay, but also water content, physical appearance, packaging, documentation, and storage conditions. Because product behavior can vary with handling and lot characteristics, the supplier specification and applicable safety data sheet should remain the final reference for purchasing and use.
Pyridine-3-boronic acid is also known as 3-pyridylboronic acid or pyridine-3-boronyl compound in some technical contexts. The pyridine nitrogen provides a basic and coordinating site, while the boronic acid group serves as a reactive coupling handle. This combination gives the molecule value in medicinal chemistry, materials research, and the preparation of heteroaryl-substituted compounds.
The boronic acid group can participate in carbon–carbon bond-forming chemistry under suitable reaction conditions. In a typical Suzuki–Miyaura coupling, the boronic acid reacts with an aryl or heteroaryl halide in the presence of an appropriate catalyst, base, solvent system, and controlled temperature. The exact yield and reaction profile depend on the reaction design, substrate combination, catalyst system, and handling of the boronic acid.
| Item | Reference information |
|---|---|
| Product name | Pyridine-3-boronic acid |
| CAS number | 1692-25-7 |
| Molecular formula | C5H6BNO2 |
| Approximate molecular weight | 122.92 g/mol |
| Functional groups | Pyridine nitrogen and boronic acid |
The material is generally handled as a solid chemical intermediate, although the exact appearance may vary by manufacturing lot and packaging conditions. It may be sensitive to moisture, prolonged exposure to air, or unsuitable storage environments, so buyers should confirm the supplier’s current handling instructions. A certificate of analysis should be reviewed for the delivered lot rather than relying only on general catalog information.
The principal use of Pyridine-3-boronic acid is as a heteroaryl building block in organic synthesis. Its 3-pyridyl group can be incorporated into target molecules where the pyridine ring contributes polarity, nitrogen-based coordination, or specific molecular recognition properties. This makes the compound relevant to discovery chemistry and route development where small structural changes can affect biological or material performance.
In Suzuki–Miyaura chemistry, Pyridine-3-boronic acid can be coupled with suitable aryl, heteroaryl, or vinyl electrophiles. The resulting carbon–carbon bond may be used to prepare biaryl and heteroaryl structures for further evaluation. Reaction optimization commonly considers catalyst loading, base selection, solvent, temperature, reaction time, substrate stability, and the potential for protodeboronation.
Pyridine-containing fragments are frequently explored during the design of small molecules because the ring can influence hydrogen-bonding behavior, polarity, and molecular conformation. Pyridine-3-boronic acid can therefore serve as an intermediate during the synthesis of analog libraries and lead-optimization compounds. It is a research and manufacturing input, not a finished pharmaceutical ingredient, and its suitability must be assessed within the complete synthetic route.
Heteroaryl boronic acids may also be selected for the preparation of specialty intermediates, crop-protection research compounds, ligands, and functional organic molecules. The final application depends on the downstream structure and regulatory pathway. We recommend that buyers define the intended use before ordering so that documentation, packaging, and technical support can be aligned with the project.
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For B2B purchasing, “the same chemical” does not always mean “the same production requirement.” A discovery laboratory may prioritize small pack availability and rapid documentation, while a process-development team may require consistent assay, controlled water content, larger packaging, and lot-to-lot supply planning. We help customers translate their route requirements into a practical product specification without assuming that one specification fits every application.
Not every project requires every test, and additional analysis can affect cost and lead time. We recommend first identifying the critical quality attributes for the intended reaction, then requesting only the controls that support a clear technical decision. This approach can reduce unnecessary complexity while protecting process performance.
Pyridine-3-boronic acid should be stored in a cool, dry, and well-controlled area in its original, properly closed container. Many boronic acid intermediates require protection from excessive moisture and prolonged exposure to unsuitable atmospheric conditions, so minimizing container opening time is a sensible practice. The supplier’s label, SDS, and lot-specific instructions should take priority over general guidance.
When handling the material, personnel should use suitable laboratory controls, including appropriate gloves, eye protection, protective clothing, and ventilation based on the risk assessment. Avoid generating unnecessary dust during transfer or weighing, and keep the working area clean. If material is repacked, the new container should be compatible, clearly labeled, tightly closed, and traceable to the original lot.
Storage temperature should be selected according to the manufacturer’s stated recommendation rather than an assumed universal value. For example, a buyer should not automatically place every boronic acid in refrigerated storage without confirming the product documentation and the effect of condensation during removal. Controlled storage, consistent handling, and limited exposure are more defensible practices than relying on a single temperature number.
A suitable supplier should be able to confirm chemical identity, provide consistent batch documentation, and communicate clearly about packaging and lead time. For Pyridine-3-boronic acid, buyers should ask whether the quoted material is available from regular stock or produced against order. They should also clarify the minimum order quantity, sample policy, shipping conditions, and the process for handling a quality question.
At Maison Chemical, we support B2B buyers by discussing product identity, specification requirements, pack size, documentation, and delivery planning before quotation. Where a standard specification is not sufficient, we can review the requested analytical and packaging requirements with our technical and supply teams. Any final offer remains subject to product availability, confirmed specifications, and the destination’s applicable transport and regulatory requirements.
Pyridine-3-boronic acid CAS 1692-25-7 is a practical choice when a synthesis requires introduction of a 3-pyridyl group through a boronic acid coupling handle. Its value comes from combining a reactive boronic acid function with a pyridine ring that can contribute useful chemical properties to the final molecule. However, successful sourcing depends on more than the CAS number alone.
As a next step, define your target reaction, required purity, water and impurity limits, pack size, and delivery schedule. Then request the current specification and certificate of analysis before approving the material. Contact Maison Chemical with your required quantity and documentation needs, and we can help evaluate a suitable supply option for your organic synthesis program.
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