4-Trifluoromethylphenylboronic acid, also called (4-trifluoromethyl)phenylboronic acid, is an aryl boronic acid used mainly as a coupling reagent and building block in organic synthesis. Its commonly reported molecular formula is C7H6BF3O2, with a molecular weight of approximately 189.93 g/mol, and its CAS Registry Number is 128796-39-4. I recommend evaluating this material by identity, assay, water content, physical form, packaging, documentation, and supply continuity rather than by price alone.
For most purchasing projects, the correct specification depends on the intended reaction, scale, and downstream quality requirements. I use supplier quotations, a current certificate of analysis, analytical data, and a clearly defined delivery scope to compare available material. Buyers should also confirm whether they need research-grade, synthesis-grade, or a project-specific custom specification.
This guide is intended for pharmaceutical and agrochemical research teams, contract development and manufacturing organizations, fine chemical distributors, university laboratories, and procurement professionals sourcing aryl boronic acids. It is also useful for buyers screening a new supplier before placing a pilot or production-related order. The recommendations apply to both small laboratory quantities and larger commercial sourcing programs, although exact commercial terms must be confirmed for each inquiry.
4-Trifluoromethylphenylboronic acid is an aromatic boronic acid containing a boronic acid group and a para-trifluoromethyl substituent on the benzene ring. The boronic acid functionality can participate in palladium-catalyzed Suzuki–Miyaura cross-coupling with suitable aryl or vinyl halides and related electrophiles. The trifluoromethyl group can modify the electronic and lipophilic characteristics of the resulting molecule, which is why this building block appears in medicinal chemistry and advanced intermediate research.
Its structure contains one boron atom, three fluorine atoms, two oxygen atoms, and a molecular weight near 189.93 g/mol. These values are useful for reaction calculations, inventory systems, and analytical method setup, but they should still be checked against the supplier’s current product documentation. PubChem identifies the compound using CAS 128796-39-4 and provides structure and chemical-property information for reference.
Source: National Library of Medicine, PubChem.
The primary synthetic use is as an aryl boronic acid coupling partner. In a typical development workflow, chemists screen the boronic acid with an aryl, heteroaryl, or vinyl halide under an appropriate catalyst, base, solvent, and temperature system. The actual yield and selectivity depend on the reaction design, substrate compatibility, catalyst loading, water tolerance, and work-up conditions, so I do not treat the compound as a guaranteed solution for every coupling reaction.
Researchers may use this building block to introduce a para-trifluoromethyl-substituted aryl group into lead compounds and analog libraries. The material can support structure–activity relationship studies when a fluorinated aromatic substituent is required. Whether it is suitable for a specific program should be confirmed through reaction screening and the project’s impurity-control requirements.
Custom synthesis organizations may use 4-trifluoromethylphenylboronic acid as an intermediate in multi-step routes. It can be considered when a downstream molecule requires a carbon–carbon bond formed through cross-coupling. For scale-up, I recommend reviewing not only reaction performance but also residual palladium control, filtration behavior, solvent compatibility, and the availability of reproducible batches.
The following information provides a practical purchasing framework rather than a substitute for a batch-specific certificate of analysis. A supplier should define the actual release limits, test methods, and retest or shelf-life policy in the quotation or quality documentation. If a value is critical to your process, I recommend making it a written purchase specification.
| Item | Reference or purchasing consideration |
|---|---|
| Product name | 4-Trifluoromethylphenylboronic acid |
| CAS number | 128796-39-4 |
| Molecular formula | C7H6BF3O2 |
| Molecular weight | Approximately 189.93 g/mol |
| Functional group | Aryl boronic acid with a para-trifluoromethyl substituent |
| Typical commercial form | Solid material; confirm appearance and particle characteristics by batch |
| Critical analytical items | Assay, identity, water, related substances, residual solvents, and elemental impurities where applicable |
I advise buyers not to copy an assumed assay, melting point, water content, or storage period into a purchase order without confirmation. Different suppliers may use different analytical methods, reporting conventions, and release criteria. For regulated or scale-sensitive work, the current SDS, specification sheet, COA, and shipping classification should be reviewed before approval.
Source: PubChem is a useful public reference for chemical identity and calculated properties; the supplier’s batch documentation remains the controlling source for commercial quality data.
First, I identify whether the material is intended for route scouting, medicinal chemistry, process development, analytical reference use, or commercial intermediate manufacture. A discovery project may prioritize fast delivery and a suitable research-grade assay, while a scale-up project may require tighter impurity controls and documented change management. This distinction prevents buyers from comparing products that appear identical but serve different quality systems.
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At minimum, I request confirmation of identity, assay method, water content, related substances, residual solvents, and batch traceability. If the compound will enter a regulated manufacturing route, I also ask whether elemental impurities, residual palladium, and other process-related impurities can be evaluated when relevant. The acceptable limits should come from the process risk assessment rather than from an unverified market assumption.
Pack size affects handling, exposure to moisture, inventory cost, and the risk of holding excess material. For example, a laboratory may request a pack measured in grams, whereas a development project may require kilograms after successful process confirmation. I recommend confirming the available package sizes, repacking controls, labeling, and whether multiple batches can be supplied for a larger order.
Ask for the production or dispatch location, lead-time estimate, packaging description, SDS, COA format, and transport conditions. Confirm whether the quoted lead time is based on ready stock, standard production, or a new manufacturing campaign. Delivery terms, import requirements, temperature or moisture precautions, and document language can materially affect the real cost of sourcing.
Price per kilogram is only one part of total procurement cost. A lower quotation may become less attractive if it requires a long lead time, lacks the necessary analytical documentation, or cannot support the next project phase. I recommend using a weighted supplier scorecard that gives separate scores to quality, service, delivery reliability, commercial terms, and technical responsiveness.
Pricing for 4-trifluoromethylphenylboronic acid can vary with order quantity, assay requirement, packaging, production status, shipping destination, and whether the material is from an existing batch or made to order. Because these variables change over time, I do not present an unsupported fixed price or universal MOQ. A valid quotation should state currency, Incoterms, pack size, validity period, payment terms, and whether taxes or freight are included.
Lead time should be separated into quotation time, sample preparation, production, quality release, and transportation. For a time-sensitive project, I ask the supplier to identify which stages are already completed and which remain dependent on production scheduling. Buyers should also allow time for incoming inspection, analytical confirmation, and any import or customs process.
A product name can look identical across suppliers while the assay method, water specification, impurity profile, and packaging differ. I therefore compare the complete specification and a representative COA instead of comparing only the CAS number and nominal purity. This is especially important when the material is used in a sensitive coupling step.
Boronic acids may require controlled handling according to the supplier’s SDS and product instructions. Buyers should review the stated storage temperature, container type, resealing instructions, and retest policy before receiving the material. If moisture is a process concern, water content should be requested as a measured batch attribute rather than assumed from the product name.
Large purchasing commitments made before route screening can create unnecessary inventory risk. I generally recommend beginning with a technically appropriate evaluation quantity, confirming reaction performance, and then aligning the commercial order with the validated process. The exact quantity depends on the reaction scale, number of experiments, and expected recovery.
At Maison Chemical, I approach 4-trifluoromethylphenylboronic acid sourcing as a specification-matching and supply-planning exercise. Our team can review your requested CAS number, target quantity, quality requirements, packaging preference, destination, and documentation needs before preparing a quotation. Availability, MOQ, lead time, and batch-specific data should be confirmed for each inquiry rather than assumed.
For a more useful quotation, please provide the expected quantity in grams or kilograms, required assay or impurity limits, intended application, preferred delivery schedule, and destination country. If you need a sample, include the evaluation quantity and the analytical documents required for approval. This information helps us determine whether a standard supply option or a project-specific solution is more appropriate.
4-Trifluoromethylphenylboronic acid CAS 128796-39-4 is primarily a fluorinated aryl building block for cross-coupling and advanced organic synthesis. The most reliable buying decision comes from matching the material’s analytical profile and documentation to the intended reaction and quality system. I recommend confirming identity, assay, water, impurities, packaging, MOQ, lead time, and supply continuity before approving a supplier.
If you are evaluating this product for laboratory research, process development, or recurring commercial supply, send Maison Chemical your target quantity and required specification. We can then assess the appropriate supply route, documentation package, packaging format, and delivery plan for your project.
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