4-Methoxyphenylboronic acid, also called 4-methoxybenzeneboronic acid, is an aryl boronic acid used mainly as a coupling partner in synthetic organic chemistry. Its CAS number is 5720-07-0, and its molecular formula is C7H9BO3 with a molecular weight of approximately 151.96 g/mol. The most important purchasing considerations are identity, assay, impurity profile, packaging, documentation, and reliable supply continuity.
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At Maison Chemical, I position this product for research, pharmaceutical, agrochemical, specialty chemical, and custom synthesis procurement. The material is generally selected when a para-methoxy-substituted phenyl group is required in a Suzuki–Miyaura or related boron-mediated transformation. Because final suitability depends on the reaction and downstream process, buyers should confirm the required grade and analytical specifications before placing a production order.
4-Methoxyphenylboronic acid is an aryl boronic acid containing a methoxy group in the para position of the phenyl ring. The boronic acid functional group can participate in transmetalation and subsequent bond formation under suitable catalytic and basic conditions. This reactivity makes the compound a practical intermediate for introducing a 4-methoxyphenyl fragment into more complex molecules.
The product is commonly supplied as a solid for laboratory or industrial synthesis. Its exact appearance, particle characteristics, water content, and stability can vary with manufacturing route, purification, drying, and packaging. I therefore recommend confirming the current certificate of analysis and safety documentation for the specific batch being considered.
The defining function of this material is its boronic acid group, which is commonly used in palladium-catalyzed Suzuki–Miyaura coupling with aryl or heteroaryl halides. The reaction can form a new carbon–carbon bond while transferring the substituted phenyl group from boron to the coupling partner. Actual conversion and selectivity depend on the catalyst, base, solvent, temperature, substrate structure, and reaction work-up.
| Item | Reference information | Procurement relevance |
|---|---|---|
| Product name | 4-Methoxyphenylboronic acid | Confirms the intended para-methoxy aryl boronic acid |
| CAS number | 5720-07-0 | Supports identity verification and purchasing accuracy |
| Molecular formula | C7H9BO3 | Useful for stoichiometric calculations and database matching |
| Molecular weight | Approximately 151.96 g/mol | Required for molar conversion and reaction planning |
| Functional class | Aryl boronic acid | Indicates suitability for boron-mediated synthetic applications |
For a commercial specification, I suggest reviewing assay by an appropriate chromatographic method, identification data, water content, residual solvents, inorganic residues, and any known regioisomer or starting-material impurities. A purity requirement such as 98% or higher may be appropriate for some research or process-development applications, but it should not be treated as a universal specification without batch-level confirmation. The correct limit depends on the sensitivity of the buyer’s reaction and the stage of development.
Storage and handling should follow the supplier’s current SDS and label instructions. In practice, buyers often request a dry, tightly closed package protected from excessive moisture and heat, but the precise temperature and shelf-life recommendation should be confirmed for the supplied batch. I also recommend checking whether the material is supplied as a free boronic acid rather than a protected boronate ester, because these forms are not interchangeable for every purchasing or processing requirement.
The most established use of 4-Methoxyphenylboronic acid is the preparation of biaryl and heteroaryl compounds through Suzuki–Miyaura coupling. It can be paired with suitable aryl, heteroaryl, or vinyl halides under an appropriate catalytic system. The para-methoxy substituent may also provide a useful electronic influence when the resulting aryl group is incorporated into a pharmaceutical, material, or research intermediate.
Medicinal chemistry teams may use this compound to build screening libraries or optimize aryl-substituted lead structures. Process chemistry groups may evaluate it as a route-specific intermediate when a 4-methoxyphenyl unit is required. Agrochemical and specialty chemical developers can similarly use it in discovery or intermediate synthesis, subject to their own regulatory, impurity, and scale-up requirements.
Academic laboratories, contract research organizations, and custom synthesis manufacturers may purchase this material for route scouting and parallel synthesis. It is particularly useful when a defined aryl substituent is needed across a series of analogues. For larger-scale use, the buyer should assess not only the nominal purity but also reproducibility between lots, filtration behavior, packaging suitability, and the supplier’s ability to maintain the agreed specification.
First, identify whether the requirement is for early research, process development, pilot production, or routine manufacturing. Early-stage users may prioritize availability and a practical assay specification, while regulated or scale-sensitive projects generally need tighter impurity control and more complete documentation. The intended use should determine the depth of qualification requested from the supplier.
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Confirm the CAS number, chemical name, molecular formula, molecular weight, and structure before comparing quotations. Ask whether the product is the free acid, a hydrate or solvate, or a protected derivative. These distinctions can affect weighing, stoichiometry, reaction behavior, and the amount of material required.
Request a representative certificate of analysis, SDS, product specification, and available analytical data. The COA should identify the batch and show the reported assay and relevant test results rather than presenting only a generic product description. If the material will enter a controlled process, clarify whether additional testing, retention samples, or a quality agreement is required.
Compare quotation currency, pack size, minimum order quantity, production status, payment terms, shipping method, and documentation charges. A low unit price may not represent the lowest total procurement cost if the package size, freight, customs handling, or re-testing requirements are unsuitable. For planning, ask the supplier to state the expected lead time in business days and whether the quoted lead time applies to stock or made-to-order production.
At Maison Chemical, I recommend that buyers share the intended application, target quantity, required assay, destination country, and preferred packaging at the inquiry stage. This information allows me to distinguish a laboratory sample request from a recurring commercial supply requirement. It also helps prevent avoidable quotation revisions caused by incomplete specifications.
One frequent mistake is selecting a product solely by CAS number without reviewing the actual batch specification. CAS identification confirms the substance reference, but it does not by itself guarantee a particular assay, water content, particle size, or packaging format. Another mistake is assuming that a research-grade material will automatically meet the requirements of a validated manufacturing process.
Buyers should also avoid comparing suppliers only on price per gram. A meaningful comparison should include the quantity offered, analytical documentation, delivery terms, shelf-life information, and the supplier’s ability to support repeat orders. If the material is moisture-sensitive or used in a sensitive coupling reaction, packaging and handling information can be as important as the headline purity.
Maison Chemical supplies 4-Methoxyphenylboronic acid CAS 5720-07-0 for customers evaluating research, development, and commercial synthesis needs. I can support product identification, specification alignment, quantity discussions, documentation review, and export-oriented order coordination. Availability and lead time should be confirmed against the current production and inventory schedule.
For a practical quotation, please provide the required quantity, target specification, delivery location, packaging preference, and intended use. I can then help clarify whether the available material is suitable for your project and identify any information that should be confirmed before purchase. Where a project requires recurring supply, I also recommend discussing forecast volumes and acceptance criteria in advance.
4-Methoxyphenylboronic acid CAS 5720-07-0 is a useful aryl boronic acid for introducing a 4-methoxyphenyl group, especially in Suzuki–Miyaura and related synthetic chemistry. Its approximate molecular weight of 151.96 g/mol supports straightforward stoichiometric planning, but successful procurement requires more than confirming the chemical name. Buyers should match the assay, impurity profile, packaging, documentation, and supply terms to the actual stage and risk level of the project.
The next step is to prepare a concise purchasing brief covering quantity, specification, destination, packaging, and required documents. Send these details to Maison Chemical for a commercial assessment and quotation. By evaluating both technical suitability and supply reliability, you can reduce sourcing uncertainty and make a more informed decision for 4-Methoxyphenylboronic acid procurement.
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