4-Hydroxyphenylboronic Acid CAS 71597-85-8: Uses and Procurement Guide

4-Hydroxyphenylboronic acid (CAS 71597-85-8) is an aromatic boronic acid with a phenolic hydroxyl group, commonly used as a building block in organic synthesis. Its boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura coupling, while its phenolic group provides an additional site for chemical modification. Buyers should confirm the required grade, assay, documentation, packaging, and delivery schedule before ordering. Maison Chemical can help buyers review product requirements and request a quotation for their intended use.

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Key Takeaways

• CAS 71597-85-8 identifies 4-hydroxyphenylboronic acid, a bifunctional aromatic building block.
• Its most familiar synthetic role is as an aryl coupling partner; the hydroxyl group also enables further functionalization.
• The molecular formula is C₆H₇BO₃, and the molecular weight is approximately 137.93 g/mol.
• Procurement decisions should be based on the intended reaction, required quality documentation, quantity, packaging, and confirmed lead time.
• Request a current specification and quote rather than assuming that an example purity, pack size, or delivery schedule is available.

Who This Guide Is For

This guide is intended for research chemists, process development teams, purchasing professionals, and chemical distributors evaluating 4-hydroxyphenylboronic acid. It explains the compound’s basic identity, typical synthesis roles, and practical sourcing questions. It is not a substitute for a product-specific specification, safety data sheet, or validated operating procedure. Confirm that the material and its documentation meet your organization’s requirements before use.

Basic Concept and Chemical Context

The molecule contains a phenyl ring bearing a boronic acid group and a para-position hydroxyl group. This combination makes it useful when a synthesis requires an aromatic coupling partner that also retains a handle for subsequent chemistry. The boronic acid group is often used to form a carbon–carbon bond in cross-coupling reactions, subject to the selected reaction conditions and substrate compatibility.

Identity and Reference Information

Use the CAS number together with the product name and formula when requesting a quote or checking internal records. These identifiers help reduce confusion with other hydroxy-substituted phenylboronic acids, which have different positional arrangements and may behave differently in a synthesis. Confirm the identity against the supplier’s current product documentation before placing an order.

Uses and Application Matching

Suzuki–Miyaura Coupling and Molecule Building

A common use for 4-hydroxyphenylboronic acid is as an aryl partner in Suzuki–Miyaura coupling to introduce a hydroxyphenyl unit into a target molecule. The resulting product may retain a phenolic hydroxyl group for later derivatization, depending on the reaction design. The exact suitability depends on the electrophile, catalyst system, solvent, base, and other reaction conditions; the compound should not be treated as a guaranteed fit for every coupling protocol.

Further Functionalization and Research Use

The phenolic hydroxyl group can provide a separate point for transformations such as ether or ester formation when compatible with the project’s chemistry. Boronic acids may also participate in reversible interactions with certain diol-containing molecules, but the relevance of that behavior depends on the application and conditions. Researchers should evaluate the compound against the specific reaction or study design rather than infer performance from its functional groups alone.

Material Options and Specifications to Review

Suppliers may offer product variants based on grade, assay, packaging, or documentation, but availability can vary. For a research project, a buyer may prioritize identity confirmation and a suitable assay; for a scale-up program, the team may also need tighter impurity controls, a defined test method, or additional batch documentation. State these requirements explicitly so the supplier can confirm whether the requested material is available.

What to Confirm Before Purchase

• Identity: Confirm the product name, CAS number, and molecular formula.
• Quality requirements: Specify the target assay or purity and ask which analytical method and acceptance criteria apply.
• Documentation: Request the available certificate of analysis, safety data sheet, and other documents required by your receiving or compliance process.
• Packaging: Confirm pack size, container type, labeling, and any handling requirements before shipment.
• Intended use: Explain whether the material is for laboratory evaluation, process development, or another defined use.

Do not assume that a generic product listing establishes a particular impurity profile, test method, storage period, or regulatory status. Request current batch-specific documents where needed and review them against your own acceptance criteria. For storage and handling, follow the supplier’s product documentation and applicable site procedures.

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Procurement and Supplier Evaluation Framework

Step 1: Define Quantity and Project Stage

Estimate the required amount from the planned reaction scale, expected repeat runs, and any material needed for method development. As a theoretical calculation, 1 mmol corresponds to approximately 137.93 mg of pure 4-hydroxyphenylboronic acid. A 10 mmol amount corresponds to approximately 1.3793 g on the same pure-material basis; actual weighed quantities may need adjustment according to the product assay and your procedure.

Step 2: Match the Specification to the Application

Set quality requirements according to the consequences of variation in your process. A screening experiment may have different documentation needs from a validated or larger-scale workflow. If you require a specific assay, impurity limit, analytical method, or batch record, include it in the inquiry and ask the supplier to confirm feasibility before ordering.

Step 3: Compare Price, MOQ, and Lead Time

Price depends on factors such as requested quantity, specification, packaging, and current availability. Minimum order quantity and lead time should therefore be confirmed for the exact product and delivery destination rather than assumed from general market information. Ask whether the quotation covers the requested documentation and packaging, and confirm the quote’s validity period and shipping terms.

Step 4: Evaluate the Supplier Response

A useful supplier response should clearly identify the material and address the buyer’s key requirements. Check whether the supplier can provide the requested specification and documentation, explain any deviations, and confirm the expected fulfillment schedule. If the application is sensitive to impurities or scale, discuss technical requirements before committing to a purchase.

Common Procurement Mistakes

• Ordering by a shortened name without checking the CAS number and positional isomer.
• Assuming that a listed purity, pack size, or lead time applies to every batch or destination.
• Failing to request the analytical method or batch documentation needed for internal release.
• Choosing a quantity without accounting for assay, planned experiments, and receiving requirements.
• Leaving shipping, packaging, or delivery expectations until after the purchase order is issued.

Clear specifications reduce avoidable clarification and help both the buyer and supplier assess whether an order is feasible. When requirements are not yet fixed, identify what is mandatory and what can be flexible. This makes quotation comparisons more meaningful and supports a smoother purchasing decision.

Maison Chemical Supplier Support

Maison Chemical supports B2B inquiries for 4-hydroxyphenylboronic acid and can discuss product requirements, requested quantity, documentation, and delivery needs. We recommend including CAS 71597-85-8, the target specification, pack-size preference, destination, and intended application in your inquiry. Our team can then confirm the details available for the requested order and provide a quotation for review.

Conclusion and Next Steps

4-Hydroxyphenylboronic acid CAS 71597-85-8 is a useful bifunctional aromatic building block, particularly when a synthesis calls for a hydroxyphenyl group introduced through boronic-acid coupling chemistry. To procure it effectively, verify the identity, define application-specific quality and documentation requirements, and confirm quantity, packaging, price, MOQ, and lead time with the supplier. For a quotation from Maison Chemical, send your target specification, required amount, destination, and any documentation needs so the request can be assessed against your project requirements.